Notes on Skin

Why Human and Mammal Exosomes Are Banned

Human-derived and mammalian exosome products are mostly banned due to the potential for disease and viral transmission from host to recipient. Salmon-derived exosomes present a lower risk profile and are used for their safety and efficacy, while plant-derived exosomes are...

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What's Actually Inside an Exosome (and Why It Matters)

E-50 Skin Exosomes are biologically active extracellular vesicles containing a precise composition of growth factors (EGF, TGF-β, IGF-1, FGF) and cytokines (IL-1β, IL-6, TNF-α). EGF stimulates keratinocyte proliferation and collagen synthesis, TGF-β regulates inflammation and drives matrix remodeling, IGF-1 promotes...

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Why Billions of Exosomes Don't Matter If They Aren't Real

High exosome counts are meaningless without verification that the particles are true exosomes containing bioactive molecules. Ultracentrifugation captures debris along with exosomes, but only Nanoparticle Tracking Analysis combined with Western Blot testing for marker proteins like CD63, CD9, and CD81...

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Three Questions to Ask Before Choosing an Exosome Treatment

Before choosing an exosome treatment, evaluate three criteria: the source (species and cell type), purity (whether you're getting real exosomes or debris), and endogenous content (whether the vesicles contain growth factors, mRNA, and signaling molecules). Safety, compatibility, and regeneration depend...

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